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Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for Longevity

Time: 2019-07-10


Anti-Aging Researcher David Sinclair Takes Metformin, NMN, NAD for Longevity


David Sinclair is working on various anti-aging molecules. He was famous for discovering the anti-aging effect of resveratrol and sirtuins. David Sinclair was interviewed on the Joe Rogan show about antiaging.

In 2013, GlaxoSmithKline shutdown Sirtris (David Sinclair’s company) about five years after spending $720 million to buy Sirtris.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging.

Life Biosciences was co-founded in 2017 by David A. Sinclair, PhD, AO, a professor in the Department of Genetics at Harvard Medical School, and Tristan Edwards, an investment professional who developed its innovative company structure.

Sinclair’s lab continues to work on resveratrol and analogs of it, as well as on mitochondria and NAD, all directed to understanding aging and how to prevent it.

His antiaging regimen is to activate pathways to improve the bodies defenses against aging.

He is testing NMN on human subjects. He describes NMN is fuel for sirtuins. NMN is related to NR. NR increases the levels of NAD. Sirtuins need NAD to work. We lose NAD as we age. We have half of the NAD by the time we are 50.

He takes a gram of NMN (Nicotinamide MonoNucleotide) and takes half a gram resveratrol in the morning with yogurt.

He is personally taking 1 gram of Metformin once a day at night.

He gives himself temperature treatments. He exposes himself to heat in a hot tub and then cold in a cold bath. The temperature treatments are again to activate the pathways to aging defense.

He also performs intermittent fasting. He skips meals and is a night time eater. He limits is sugar and carbs. He limits his eating of meat.

He is not taking Rapamycin because of concern over side-effects.

Anti-oxidants are a failure in the anti-aging field.



Metro Biotech makes a super-NAD booster which is called MIB-626. They hope to get it on the market to treat diseases in three years. It is in clinical trials for safety now.

Research has found the lining of blood vessels needs NAD.

SRT-2104 has had successful antiaging effects.